The MTHFR Mutation: How It Affects Your Health and What You Can Do About It
Imagine feeling persistently fatigued despite adequate sleep, struggling with mood swings, or experiencing recurring health issues without a clear explanation. For many, these symptoms remain a mystery, but for some, the answer lies within their genetic code. The MTHFR gene mutation—a genetic variation that affects how the body processes folate and homocysteine—has garnered increasing attention for its role in various health conditions. Understanding and addressing this gene mutation can be life-changing, and testing for it is the first step.
What is the MTHFR Gene?
MTHFR, Methyl-tetrahydrofolate reductase is an enzyme that is produced by the MTHFR gene and is important for efficient methylation in every cell of your body. Methylation is a primary method of removing toxins from the body, including heavy metals. In addition, it aids in the synthesis of neurotransmitters and proteins as well as folate metabolism for cardiovascular health, reduces inflammation and helps protect mitochondria among other processes. Methylation aids in the recycling of homocysteine (which in high levels is toxic to blood vessels) to methionine from which it is biosynthesized.
Methionine is important in building proteins, utilizing antioxidants and assisting your liver in processing fats. It also helps reduce depression and inflammation. Methionine is then converted in your liver to SAM-e (s-adenosylmethionine) which not only acts as an anti-inflammatory, it supports your immune system, helps reduces the breakdown of serotonin, dopamine and melatonin and is involved in the growth, repair & maintenance of your cells. Now this weird sounding gene looks kind of important, right?
There are over 50 variants of the MTHFR gene, but two forms are known to be of prime importance, 677T and 1298C. The 677T type is more commonly associated with early heart disease and stroke while the 1298C is associated with a variety of chronic disease but either mutation may result in an array of health problems. And just having the mutation does not mean you are destined to develop these conditions, but it raises your risk and significantly in some cases.
It is estimated that over 40% of the population has some form of this gene mutation. Fortunately, there is an easy way to test for it and to compensate for it.
Symptoms and Health Implications
An MTHFR mutation is linked to a wide range of symptoms and health issues, including:
- Chronic fatigue
- Depression and anxiety
- Migraines
- Cardiovascular disease due to elevated homocysteine
- Recurrent miscarriages
- Poor detoxification leading to sensitivity to environmental toxins
While these symptoms are not exclusive to MTHFR mutations, individuals with a positive test often find relief through targeted interventions. Other will have no real symptoms but are at higher risk for heart disease or dementia with age.
Testing and Treatment
Testing for the MTHFR gene is straightforward and non-invasive. At Besana Health and Wellness in Denver, we offer comprehensive genetic testing to identify MTHFR mutations, through a blood draw. Once your results are available, our experts help interpret the findings and create a personalized treatment plan tailored to your unique needs.
For those who test positive, treatment focuses on optimizing methylation and reducing homocysteine levels. Patients with any mutation variant in the MTHFR gene should avoid folic acid, the synthetic form of folate. Folic acid is fortified or “enriched” and is a chemical form of folate into bread and rice and used for supplements. Folate is found in green leafy veggies, Romaine lettuce, spinach, asparagus, turnip greens, mustard greens, parsley, collard greens, broccoli, cauliflower, beets and lentils. Folate may be also taken as a supplement, just make sure that is really what you’re taking.
Xymogen’s Methyl Protect is a supplement specifically designed to support these processes. It provides bioavailable forms of folate (L-methylfolate), vitamin B12 (methylcobalamin), and vitamin B6 as well as Betaine TMS, which helps lower homocysteine—key nutrients for individuals with MTHFR mutations. Supplementation is life long, as this mutation will not change. Be aware that you may be at higher risk of drug sensitivities to nitrous oxide, anesthesia, anti-epileptics and methotrexate.
Lifestyle Adjustments
Beyond supplementation, lifestyle changes play a crucial role in managing MTHFR-related health concerns. Here are some lesser-known tips:
- Choose the Right Folate: Synthetic folic acid, commonly found in fortified foods or enriched as a substitute for folate and is not well well-metabolized by anyone, but individuals with MTHFR mutations are more affected. Opt for natural sources of folate, such as leafy greens, avocados, legumes, 100% grass fed beef or eggs.
- Limit Toxins: Impaired detoxification can exacerbate symptoms. Reduce exposure to environmental toxins by choosing organic foods, using natural cleaning and personal care products, and avoiding unnecessary medications.
- Support Gut Health: A healthy gut microbiome aids in nutrient absorption and detoxification. Incorporate fermented foods, prebiotics, and probiotics into your diet, and eliminate wheat, corn and soy to avoid the toxic herbicide glyphosate.
- Stress Management: Chronic stress can worsen methylation issues. Practices like meditation, yoga, and adequate sleep are essential for maintaining balance.
- Regular Monitoring: Keep an eye on homocysteine levels through routine blood tests, as elevated levels can indicate the need for adjustments in your treatment plan. Consider optimal range is between 6-7 vs. the “normal” range for most labs.
Why Testing Matters
Understanding your MTHFR status empowers you to take proactive steps toward better health. At Besana Health and Wellness, we go beyond the test results. We offer holistic support to address symptoms and improve your overall well-being. From genetic testing to customized treatments, our team is dedicated to helping you feel your best.
Are you ready to unlock the secrets of your genetic code and take control of your health? Start your journey today by exploring the benefits of MTHFR genetic testing and personalized care.
